Kabuto Yakushi claimed during the Fourth Shinobi World War that Hashirama’s expertise had yet to be matched, with people concerning his abilities in a creative light. Madara openly admitted inferiority to Hashirama since childhood, and even with the Eternal Mangekyō Sharingan and the Nine-Tails at his disposal, he could never defeat Hashirama in their lifetimes. Hashirama was skilled in all five basic nature transformations, along with Yin and Yang Release. He was most popular for his use of Wood Release, a combination of earth and water-natured chakra, creating wood and plants from the ground or his very being of various sizes that he operated to his purposes.
This ability was evidently absolute to him as no one else has naturally obtain this power; any replications are noticeably weaker than Hashirama’s abilities. Hashirama could also use senjutsu and enter Sage Mode — a feat he could perform right away and, with the Wood Release, he was able to control the Tailed Beasts.